Phone: 1-973-200-6661


Cellular senescence is the cause of the production of specific molecules known as the Senescence Associated Secretory Phenotype (SASP) factors “toxifying” the skin tissue environment thus accelerating the age-dependent tissue disorganization. The production of SASP factors is under the control of the synthesis regulator NFkB that is itself rapidly activated as cells become senescent. Bioptimized™ Guava is an active ingredient that inhibits the activation of NFkB and the production of SASP factors. Bioptimized™ Bioptimized™ Guava can be positioned as a Skin Aging Detox System™ and also The Skin Youth Element™. It is a key ingredient for all anti-aging formulations.

  • Actions and Efficacy

    • Inhibition of NFkB activation
      • Bioptimized™ Guava blocks the degradation of the NFkB inhibitor, I?B and thus locks NFkB in an inactive configuration
    • Inhibition of eotaxin production
    • Inhibition of COX-2/PGE2 pathways
    • Inhibition of iNOS/Nitric oxide pathways
  • Technical information

    • 100% water soluble
    • Made with non-GMO propanediol
    • Recommended concentration in formulation: 0.2-1%
    • INCI: Propanediol, Psidium Guajava Leaf Extract, Saccharomyces Lysate Extract
  • Applications

    • Anti-aging, anti-wrinkle
    • Diminution of senescence-related chronic inflammation
    • Reduction of skin damage induced by senescence
    • Prevention of tissue disorganization caused by the aging process
    • Reduction of age-related SASP side effects
    • Protection/repair of environmental damages
    • Anti-pollution
    • Sun care
    • After sun care
    • Sunscreens
  • Formulation

  • Publication

active ingredient, skin care, anti-aging, anti-wrinkle, cellular senescence, Guava leaf, SASP inhibition, NFkB inhibition