Cellular senescence is the cause of the production of specific molecules known as the Senescence Associated Secretory Phenotype (SASP) factors “toxifying” the skin tissue environment thus accelerating the age-dependent tissue disorganization. The production of SASP factors is under the control of the synthesis regulator NFkB that is itself rapidly activated as cells become senescent. Bioptimized™ Guava is an active ingredient that inhibits the activation of NFkB and the production of SASP factors. Bioptimized™ Bioptimized™ Guava can be positioned as a Skin Aging Detox System™ and also The Skin Youth Element™. It is a key ingredient for all anti-aging formulations.
Actions and Efficacy
- Inhibition of NFkB activation
- Bioptimized™ Guava blocks the degradation of the NFkB inhibitor, I?B and thus locks NFkB in an inactive configuration
- Inhibition of eotaxin production
- Inhibition of COX-2/PGE2 pathways
- Inhibition of iNOS/Nitric oxide pathways
- Inhibition of NFkB activation
Technical information
- 100% water soluble
- Made with non-GMO propanediol
- Recommended concentration in formulation: 0.2-1%
- INCI: Propanediol, Psidium Guajava Leaf Extract, Saccharomyces Lysate Extract
Applications
- Anti-aging, anti-wrinkle
- Diminution of senescence-related chronic inflammation
- Reduction of skin damage induced by senescence
- Prevention of tissue disorganization caused by the aging process
- Reduction of age-related SASP side effects
- Protection/repair of environmental damages
- Anti-pollution
- Sun care
- After sun care
- Sunscreens
Formulation
Publication
