Cellular senescence is the cause of the production of specific molecules known as the Senescence Associated Secretory Phenotype (SASP) factors “toxifying” the skin tissue environment, thus accelerating the age-dependent tissue disorganization. The production of SASP factors is controlled by the synthesis regulator NFkB which is rapidly activated as cells become senescent. Bioptimized™ Guava is an active ingredient that inhibits the activation of NFkB and the production of SASP factors preventing skin aging signs appearance. Bioptimized™ Guava is a key ingredient for all anti-aging formulations; it can be used as the main ingredient for a potent anti-aging activity or in combination with «traditional» anti-aging active ingredients to boost their efficacy.
Actions and Efficacy
- Inhibition of NFkB activation
- Bioptimized™ Guava blocks the degradation of the NFkB inhibitor, iKB and thus locks NFkB in an inactive configuration
- Inhibition of eotaxin production
- Inhibition of COX-2/PGE2 pathways
- Inhibition of iNOS/Nitric oxide pathways
- Inflamm-aging response
- Improvement in
- skin firmness,
- skin elasticity
- skin hydration
- Decrease in
- wrinkle depth
- physiological and UV-induced skin oxidative damage
- Anti-aging booster
- Skin Aging Detox System
- The Skin Youth Element
- Inhibition of NFkB activation
Technical information
- 100% water soluble
- Made with non-GMO propanediol
- Recommended concentration in formulation: 0.5-3%
- INCI: Propanediol, Psidium Guajava Leaf Extract, Saccharomyces Lysate Extract
Applications
- Anti-aging, anti-wrinkle
- Diminution of senescence-related chronic inflammation
- Reduction of skin damage induced by senescence
- Prevention of tissue disorganization caused by the aging process
- Reduction of age-related SASP side effects
- Protection/repair of environmental damages
- Sun care
- After sun care
- Functional make-up
Formulation
Publication
